01 - Gently pat the catfish fillets dry using paper towels to remove excess moisture.
02 - In a shallow dish, whisk together the buttermilk and hot sauce. Submerge the catfish fillets, ensuring they are fully coated. Allow to marinate for 10 to 15 minutes.
03 - Combine the cornmeal, all-purpose flour, Cajun seasoning, salt, black pepper, and paprika in a separate shallow dish. Whisk until thoroughly blended.
04 - Pour vegetable oil into a deep skillet or fryer and heat to 350°F (175°C). Use an instant-read thermometer to monitor the temperature.
05 - Carefully remove each fillet from the buttermilk, allowing any excess to drip away. Dredge the fillets in the cornmeal mixture, pressing lightly to ensure an even and complete coating.
06 - Working in batches, carefully lower the breaded fillets into the hot oil. Fry for 4 to 5 minutes per side, or until golden brown and flaky when tested with a fork.
07 - Transfer the fried catfish to a wire rack or a plate lined with paper towels to drain any excess oil.
08 - Serve the fried catfish immediately, accompanied by fresh lemon wedges and tartar sauce, if preferred.